Angiotensin I Converting Enzyme 1 anticorps (CF®594)

N° du produit ABIN7649504

L’anticorps Souris Monoclonal anti-Angiotensin I Converting Enzyme 1 a été validé pour IHC et IHC (fp). Il convient pour détecter Angiotensin I Converting Enzyme 1 dans des échantillons de Humain.

Aperçu rapide pour Angiotensin I Converting Enzyme 1 anticorps (CF®594) (ABIN7649504)

Antigène: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Angiotensin I Converting Enzyme 1 est conjugé à/à la CF®594

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: 9B9

Détail du produit anti-Angiotensin I Converting Enzyme 1 anticorps (CF®594)

Fonction: Angiotensin I Converting Enzyme (ACE) / CD143(9B9), CF594 conjugate

Attributs du produit: Angiotensin-converting enzyme (ACE), also known as CD143, encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Full-length recombinant human ACE/CD143 protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur Angiotensin I Converting Enzyme 1

Antigène: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Autre désignation: Angiotensin I Converting Enzyme

Sujet:

Synonyms: angiotensin 1 converting enzyme, angiotensin-converting enzyme, ACE, carboxycathepsin, CD143, dipeptidyl carboxypeptidase 1, Kininase II, peptidase P

Gene Symbol: ACE

Poids moléculaire: 195 kDa

ID gène: 1636

UniProt: P12821

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration